Acquired perforating dermatosis: A clinicopathologic study, and the features of dermoscopy and reflective confocal microscopy of 37 cases

Background Acquired perforating dermatosis (APD) is a rare skin condition characterized by degenerated materials eliminated from the dermis. Several retrospective studies on APD have been reported; however, few data are available Chinese and their features dermoscopy reflective confocal microscope (RCM) assays. Objective The aim of this study was to retrospectively evaluate clinical histopathologic 37 acquired cases, assess RCM. Methods Thirty-seven patients were enrolled in our study. We histopathological features, concomitant diseases, treatment responses, RCM findings. Results Pruritus most common symptom, with lower extremities as predilection sites (86.5%, n = 32; 91.9%, 34, respectively). Concomitant diseases found 34 (92.6%), among which diabetes mellitus common, followed thyroid nodules, allergic dermatosis, chronic renal insufficiency. Dermoscopy assays performed 11 patients. typical images hyperreflective cord-like structures epidermis fully developed lesions showed central ulceration peripheral hairpin-like or loop-like capillaries characteristic garland arrangements. Conclusion an uncommon disorder associated various systemic conditions individuals. Thyroid disorders overlooked complication may play important role development APD. results indicate that noninvasive examination helpful rapid diagnosis early intervention